Publications

2025

• Takebe K., Miyakawa S., Sangawa T., Suzuki M., Matsumoto A., Oogai Y., Yamaguchi M., Sumitomo T., Fukuzawa K., Kawabata S., Nakata M. Combined structural and FMO-based insights into shaft pilin polymerization mechanism in Streptococcus sanguinis. Int. J. Biol. Macromol. Vol. 332. 148264. 2025.
• Shinjyo N., Kimura H., Yoshihara T., Suzuki J., Yamaguchi M., Kawabata S., Okabe Y. Aldehyde metabolism governs resilience of mucociliary clearance to air pollution exposure. J. Clin. Invest. Vol. 135. e191276. 2025.
• Ono M., Yamaguchi M.†, Motooka D., Hirose Y., Higashi K., Sumitomo T., Miyoshi-Akiyama T., Okuno R., Yamaguchi T., Kawahara R., Otsuka H., Nakanishi N., Kazawa Y., Nakagawa C., Yamaguchi R., Sakai H., Matsumoto Y., Ikebe T., Kawabata S. Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections. eLife. Vol. 14. RP101938. 2025. †corresponding author.
• Takemoto N., Ogura K., Gao Y., Okuno R., Yamaguchi M., Hirose Y., Ono M., Kawabata S., Ikebe T., Hamabata T., Miyoshi-Akiyama T. GAS-J, a User-Friendly Browser Application for Genome Assembly, emm-Typing, MLST Typing, and Virulence Factor Gene Detection of Streptococcus pyogenes. Microbiol Immunol. Vol. 69. 384-388. 2025.
• Yixuan L., Nakata M., Migita H., Matsumoto A., Oogai Y., Takebe K., Yamaguchi M., Okahashi N., Sumitomo T., Kawabata S. Identification of PilX, pilus component of Streptococcus sanguinis. J. Oral Biosci. Vol. 67: 100664. 2025.
• Ikeda E., Yamaguchi M., Kawabata S. The Human Oral Microbial Consortium Associated With Periodontitis Attenuates Weight Loss in Dextran Sulfate Sodium-Induced Colitis. Gastro Hep Adv. Vol. 4. 100698. 2025.
• Ikeda E., Yamaguchi M., Ono M., Kawabata S., In Vitro Acid Resistance of Pathogenic Candida Species in Simulated Gastric Fluid. Gastro Hep Adv. Vol. 4. 100591. 2025.
• Nakayama Y., Sasai M., Kuratani A., Okamoto M., Okuzaki D., Yamamoto K., Ono C., Yamaguchi M., Kawabata S., Shinjyo N., Okabe Y., Matsuura Y., Ato M., Yamamoto M. Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology. iScience, Vol. 28. 111975. 2025.
• Gong W., Ono M., Yamaguchi M.†, Motooka D., Hirose Y., Higashi K., Kobayashi M., Ikeda E., Sumitomo T., Okuno R., Yamaguchi T., Kawahara R., Otsuka H., Nakanishi N., Kazawa Y., Nakagawa C., Yamaguchi R., Sakai H., Matsumoto Y., Ikebe T., Kawabata S. A comprehensive analysis of antimicrobial resistance of clinical emm89 Streptococcus pyogenes in Japan. JAC Antimicrob Resist. Vol. 7. dlaf017. 2025. †corresponding author.
• Hata K., Wakamori K., Hirakawa-Yamamura A., Ichiyama-Kobayashi S., Yamaguchi M., Okuzaki D., Takahata Y., Murakami T., Uzawa N., Yamashiro T., Nishimura R. Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. J. Cell Physiol. Vol. 240. e31490. 2025

2024

• Iijima N., Yamaguchi M., Hayashi T., Rui Y., Ohira Y., Miyamoto Y., Niino M., Okuno T., Suzuki O., Oka M., Ishii J.K. miR-147-3p in pathogenic CD4+ T cells controls chemokine receptor expression for the development of experimental autoimmune diseases. J. Autoimmun. Vol. 149. 103319. 2024.
• Takahara Y., Sumitomo T., Kono M., Takemura M., Akamastsu Y., Hirose Y., Yamaguchi M., Nakata M., Hotomi M., Kawabata S. Pneumolysin Contributes to Dysfunction of Nasal Epithelial Barrier for Promotion of Pneumococcal Dissemination into Brain Tissue. mSphere. Vol. 9. e0065524. 2024.
• Hirose Y., Zielinski D.C., Poudel S., Rychel K., Baker J.L., Toya Y., Yamaguchi M., Heinken A., Thiele I., Kawabata S., Palsson B.O., Nizet V. A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes. mSystems. Vol. 19. e0073624. 2024.
• Ohshima J., Abe S., Morita M., Tanaka N., Yamaguchi M., Hayashi M. Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model. Sci. Rep. Vol. 14. 15502. 2024.
• Yamaguchi M.†, Uchihashi T., Kawabata S.† Hybrid sequence-based analysis reveals the distribution of bacterial species and genes in the oral microbiome at a high resolution. Biochem. Biophys. Rep. Vol. 38. 101717. 2024. †corresponding author.
• Talat D., Sumitomo T., Honda-Ogawa M., Takahara Y., Mori Y., Yamaguchi M., Nakata M., Ibrahim S. M., Kawabata S. Two-component regulatory system TCS08 of a serotype 4 strain in pneumococcal pneumonia pathogenesis. J. Oral Biosci. Vol. 66. 567-574. 2024.
• Nagata N., Kurosaka H., Higashi K., Yamaguchi M., Yamamoto S., Inubushi T., Nagata M., Ishihara Y., Yonei A., Miyashita Y., Asano Y., Sakai N., Sakata Y., Kawabata S., Yamashiro T. Characteristic craniofacial defects with novel truncated variant of USP9X. Hum Genome Var. Vol.11. 21. 2024.
• Ikeda E., Yamaguchi M., Kawabata S., Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice. Gastro Hep Advances. Vol. 3. 461-470. 2024.

Before 2023

• Kawanishi K.†, Naito-Matsui Y.†, Soares Zaramela L.†, van Sorge N.M.†, Yamaguchi M.†: Editorial: A sweet deal – Glycobiology in host-pathogen interactions. Front. Microbiol., Vol. 14. 1341820. 2023. †corresponding author. Editorial
• Takebe K., Suzuki M., Sangawa T., Kreikemeyer B., Yamaguchi M., Uzawa N., Sumitomo T., Kawabata S., Nakata M. Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch. Microbiol., Vol. 206. 4. 2023.
• Kubota S., Nakata M., Hirose Y., Yamaguchi M., Kreikemeyer B., Uzawa N., Sumitomo T., Kawabata S. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of mRNA level of transcriptional regulator. Microbiol. Immunol., Vol. 67. 319-333. 2023.
• Takemura M., Yamaguchi M.†, Kobayashi M., Sumitomo T., Hirose Y., Okuzaki D., Ono M., Motooka D., Goto K., Nakata M., Uzawa N., Kawabata S., Pneumococcal BgaA promotes host organ bleeding and coagulation in a mouse sepsis model. Front. Cell. Infect. Microbiol., Vol. 12. 844000. 2022. †corresponding author.
• Wu Z.Y.*, Campeau A.*, Liu C.H., Gonzalez D.J., Yamaguchi M., Kawabata S., Lu C.H., Lai C.Y., Chiu H.C., Chang Y.C. Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome. Virulence, Vol. 12. 2633-2647. 2021.
• Sumitomo T., Nakata M., Nagase S., Takahara Y., Honda-Ogawa M., Mori Y., Akamatsu Y., Yamaguchi M., Okamoto S., Kawabata S. GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection. mBIO, Vol. 12. e0326920. 2021.
• Yamaguchi M., Kinjo Y., Nizet V., eds. Host-pathogen Interaction During Pneumococcal Infections. Lausanne: Frontiers Media SA. 2021. doi: 10.3389/978-2-88971-888-7, Book editor
• Yamaguchi M.†, Kinjo Y.† Nizet V.† Editorial: Host-pathogen Interactions During Pneumococcal Infection. Front. Cell. Infect. Microbiol., Vol. 11. 752959. 2021. †corresponding author. Editorial
• Hirose Y., Yamaguchi M., Sumitomo T., Nakata M., Hanada T., Okuzaki D., Motooka D., Mori Y., Kawasaki H., Coady A., Uchiyama S., Hiraoka M., Zurich R.H., Amagai M., Nizet V., Kawabata S. Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep., Vol. 34. 108924. 2021.
• Yamaguchi M.†, Myo Win H. P., Higashi K., Ono M., Hirose Y., Motooka D., Okuzaki D., Aye M. M., Htun M. M., Thu H. M., Kawabata S.† Epidemiological analysis of pneumococcal strains isolated at Yangon children's hospital in Myanmar via whole-genome sequencing-based methods. Microb. Genomics, Vol. 7. 000523. 2021. †corresponding author.
• Hirose Y., Yamaguchi M., Takemoto N., Miyoshi-Akiyama T., Sumitomo T., Nakata M., Ikebe T., Hanada T., Yamaguchi T., Kawahara R., Okuno R., Otsuka H., Matsumoto Y., Terashima Y., Kazawa Y., Nakanishi N., Uchida K., Akiyama Y., Iwabuchi K., Nakagawa C., Yamamoto K., Nizet V., Kawabata S. Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019. Infect. Microbe Dis., Vol. 2. 160-166. 2020.
• Yamaguchi M.†, Takemura M., Higashi K., Goto K., Hirose Y., Sumitomo T., Nakata M., Uzawa N., Kawabata S.†, Role of BgaA as a pneumococcal virulence factor elucidated by molecular evolutionary analysis. Front. Microbiol., Vol. 11. 582437. 2020. †corresponding author.
• Otsuki M., Wada M., Yamaguchi M., Kawabata S., Maeda Y., Ikebe K. Evaluation of decontamination methods of oral biofilms formed on screw-shaped, rough and machined surface implants: an ex vivo study. Int. J. Implant Dent. Vol. 6. 18. 2020.
• Sankar S., Yamaguchi M., Kawabata S., Ponnuraj K., Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine, rabbit and porcine serum albumins. Protein J., Vol. 39. 1-9. 2020.
• Hirose Y., Yamaguchi M., Okuzaki D., Motooka D., Hamamoto H., Hanada T., Sumitomo T., Nakata M., Kawabata S. Streptococcus pyogenes transcriptome changes in inflammatory environment of necrotizing fasciitis. Appl. Environ. Microbiol., Vol. 85. e01428-19. 2019.
• Yamaguchi M.†, Hirose Y., Takemura M., Ono M., Sumitomo T., Nakata M., Terao Y., Kawabata S.† Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. Front. Cell. Infect. Microbiol., Vol. 9. 301. 2019. †corresponding author.
• Yamaguchi M.†, Goto K., Hirose Y., Yamaguchi Y., Sumitomo T., Nakata M., Nakano K., Kawabata S. Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae. Commun. Biol., Vol. 2. 96. 2019. †corresponding author.
• Hirose Y., Yamaguchi M.†, Goto K., Sumitomo T., Nakata M., Kawabata S. Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis. Virulence, Vol. 9. pp1576-1587. 2018. †corresponding author.
• Radhakrishnan D., Yamaguchi M., Kawabata S., Ponnuraj K. Streptococcus pneumoniae surface adhesin PfbA and its interaction with erythrocytes and hemoglobin. Int. J. Biol. Macromol. Vol. 120. 135-143. 2018.
• Kurosawa M., Oda M., Domon H., Isono T., Nakamura Y., Saitoh I., Hayasaki H., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Microbiol. Immunol., Vol. 62. pp617-623. 2018.
• Domon H., Nagai K., Maekawa T., Oda M., Yonezawa D., Takeda W., Hiyoshi T., Tamura H., Yamaguchi M., Kawabata S., Terao Y. Neutrophil elastase subverts the immune response by cleaving Toll-like receptors and cytokines in pneumococcal pneumonia. Front. Immunol., Vol. 9. 732. 2018.
• Hirose Y., Funahashi Y., Matsukawa Y., Majima T., Yamaguchi M., Kawabata S., Gotoh M., Yamamoto T., Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals. Cytotherapy, Vol. 20. pp589-591. 2018.
• Yamaguchi M. Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species. J. Oral Biosci. Vol. 60. pp36-40. 2018., invited review.
• Nagai K., Domon H., Maekawa T., Oda M., Hiyoshi T., Tamura H., Yonezawa D., Arai Y., Yokoji M., Tabeta K., Habuka R., Saitoh A., Yamaguchi M., Kawabata S., Terao Y. Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol., Vol. 325. pp14-22. 2018.
• Sumitomo T., Mori Y., Nakamura Y., Honda-Ogawa M., Nakagawa S., Yamaguchi M., Matsue H., Terao Y., Nakata M., Kawabata S. Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. Front. Cell. Infect. Microbiol., Vol. 8. 10. 2018.
• Kurosawa M., Oda M., Domon H., Isono T., Nakamura Y., Saitoh I., Hayasaki H., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Microb. Infect., Vol. 20 pp9-18. 2018.
• Yamaguchi M., Nakata M., Sumioka R., Hirose Y., Wada S., Akeda Y., Sumitomo T., Kawabata S. Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. Virulence, Vol. 8. pp1516-1524. 2017.
• Beulin D.S., Radhakrishnan D., Suresh S.C., Sadasivan C., Yamaguchi M., Kawabata S., Ponnuraj K. Streptococcus pneumoniae surface protein PfbA is a versatile multi-domain and multi-ligand-binding adhesin employing different binding mechanisms. FEBS J., Vol. 284. pp3404–3421. 2017.
• Oda M., Domon H., Kurosawa M., Isono T., Maekawa T., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. Front. Cell. Infect. Microbiol. Vol. 7. 300. 2017.
• Yamaguchi M., Kawabata S. Streptococcal Enolase and Immune Evasion, In Moonlighting proteins: Novel virulence factors in bacterial infections. Ed: Henderson B. Wiley Blackwell. pp269-289. 2017. invited book chapter.
• Honda-Ogawa M., Sumitomo T., Mori Y., Hamd D.T., Ogawa T., Yamaguchi M., Nakata M., Kawabata S. Streptococcus pyogenes endopeptidase O contributes to evasion from complement-mediated bacteriolysis via binding to human complement factor C1q. J. Biol. Chem. Vol. 292. pp4244-4254. 2017.
• Sumioka R., Nakata M., Okahashi N., Li Y., Wada S., Yamaguchi M., Sumitomo T., Hayashi M., Kawabata S. Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. PLoS One, Vol. 12. e0172223. 2017.
• Oogai Y., Yamaguchi M., Kawada-Matsuo M., Sumitomo T., Kawabata S., Komatsuzawa H. Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum. Appl. Environ. Microbiol. Vol. 82. pp6150-6157. 2016.
• Yamaguchi M.†, Hirose Y., Nakata M., Uchiyama S., Yamaguchi Y., Goto K., Sumitomo T., Lewis A.L., Kawabata S., Nizet V. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci. Rep. Vol. 6. 28852. 2016. †corresponding author.
• Hirose Y., Yamaguchi M., Kawabata S., Murakami M., Nakashima M., Gotoh M., Yamamoto T. Effects of Extracellular pH on Dental Pulp Cells in vitro. J. Endodont. Vol. 42. pp.735-741. 2016.
• Sumitomo T., Nakata M., Higashino M., Yamaguchi M., Kawabata S. Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Sci. Rep., Vol. 6. 20069. 2016.
• Hirose Y., Yamamoto T., Nakashima M., Funahashi Y., Matsukawa Y., Yamaguchi M., Kawabata S., Gotoh M. Injection of dental pulp stem cells promotes healing of damaged bladder tissue in a rat model of chemically induced cystitis. Cell Transplant. Vol. 25. pp425-436. 2016.
• Kang S., Watanabe M., Jacobs J.C., Yamaguchi M., Dahesh S., Nizet V., Leyh T.S., Silverman R.B. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. Eur. J. Med. Chem. Vol. 90C. pp448-461. 2015.
• Henningham A.*, Yamaguchi M.*, Aziz R.K., Kuipers K., Buffalo C.Z., Dahesh S., Choudhury B., Van Vleet J., Yamaguchi Y., Seymour L.M., Ben Zakour N.L., He L., Smith H.V., Grimwood K., Beatson S.A., Ghosh P., Walker M.J., Nizet V., Cole J.N. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J. Biol. Chem. Vol. 289. pp32303-32315. 2014. *equally contributed.
• Beulin D.S., Yamaguchi M., Kawabata S., Ponnuraj K. Crystal structure of PfbA, a surface adhesion of Streptococcus pneumoniae, provides hints into its interaction with fibronectin. Int. J. Biol. Macromol., Vol. 64. pp168-173. 2014.
• Yamaguchi M., Terao Y., Mori-Yamaguchi Y., Domon H., Sakaue Y., Yagi T., Nishino K., Yamaguchi A., Nizet V., Kawabata S. Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One, Vol. 8. e77282. 2013.
• Yamaguchi M., Terao Y., Kawabata S. Pleiotropic virulence factor - Streptococcus pyogenes fibronectin-binding proteins. Cell. Microbiol., Vol. 15. pp503-511. 2013. Review
• Sano R., Hou Y.C., Hedvat M., Correa R.G., Shu C.W., Krajewska M., Diaz P.W., Quarato G., Gottlieb R.A., Yamaguchi M., Nizet V., Dahl R., Thomas D.D., Tait S.W., Green D.R., Fisher P.B., Matsuzawa S., Reed J.C. Endoplasmic Reticulum Protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy. Genes Dev., Vol. 26. pp1041-1054. 2012.
• Mori Y.*, Yamaguchi M.*, Terao Y., Hamada S., Ooshima T., Kawabata S. α-enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps. J. Biol. Chem., Vol. 287. pp10472–10481. 2012. *equally contributed.
• Sumitomo T., Nakata M., Yamaguchi M., Terao Y., Kawabata S. S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. J. Med. Microbiol., Vol. 61. pp101-108. 2012.
• Okahashi N., Nakata M., Terao Y., Isoda R., Sakurai A., Sumitomo T., Yamaguchi M., Kimura R.K., Oiki E., Kawabata S., Ooshima T. Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. Microb. Pathog., Vol. 50. 148-154. 2011.
• Okahashi, N., Nakata M., Sakurai A., Terao Y., Hoshino T., Yamaguchi M., Isoda R., Sumitomo T., Nakano K., Kawabata S., Ooshima T. Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem. Biophys. Res. Commun., Vol. 391. pp1192-1196. 2010.
• Yamaguchi M., Minamide Y., Terao Y., Isoda R., Ogawa T., Yokota S., Hamada S., Kawabata S. Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochem. Biophys. Res. Commun., Vol. 390. pp155-160. 2009.
• Yamaguchi M., Terao Y., Mori Y., Hamada S., Kawabata S. PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis. J. Biol. Chem., Vol. 283. pp36272-36279. 2008.
• Terao Y., Mori Y., Yamaguchi M., Shimizu Y., Ooe K., Hamada S., Kawabata S. Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. J. Biol. Chem., Vol. 283. pp6253-6260. 2008.
• Yamaguchi M., Terao Y., Ogawa T., Takahashi T. Hamada S., Kawabata S. Role of Streptococcus sanguinis sortaseA in bacterial colonization. Microb. Infect., Vol. 8. pp2791-2796. 2006.
• Terao Y., Yamaguchi M., Hamada S., Kawabata S. Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. J. Biol. Chem., Vol. 281. pp14215-14223. 2006.