メニューをスキップします

国立研究開発法人 医薬基盤・健康・栄養研究所

ホーム > 細菌情報学プロジェクト > 研究業績

研究業績

2025年度

  • Takebe K., Miyakawa S., Sangawa T., Suzuki M., Matsumoto A., Oogai Y., Yamaguchi M., Sumitomo T., Fukuzawa K., Kawabata S., Nakata M. Combined structural and FMO-based insights into shaft pilin polymerization mechanism in Streptococcus sanguinis. Int. J. Biol. Macromol. Vol. 332. 148264. 2025.

  • Shinjyo N., Kimura H., Yoshihara T., Suzuki J., Yamaguchi M., Kawabata S., Okabe Y. Aldehyde metabolism governs resilience of mucociliary clearance to air pollution exposure. J. Clin. Invest. Vol. 135. e191276. 2025.

  • Ono M., Yamaguchi M.†, Motooka D., Hirose Y., Higashi K., Sumitomo T., Miyoshi-Akiyama T., Okuno R., Yamaguchi T., Kawahara R., Otsuka H., Nakanishi N., Kazawa Y., Nakagawa C., Yamaguchi R., Sakai H., Matsumoto Y., Ikebe T., Kawabata S. Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections. eLife. Vol. 14. RP101938. 2025. †corresponding author.

  • Takemoto N., Ogura K., Gao Y., Okuno R., Yamaguchi M., Hirose Y., Ono M., Kawabata S., Ikebe T., Hamabata T., Miyoshi-Akiyama T. GAS-J, a User-Friendly Browser Application for Genome Assembly, emm-Typing, MLST Typing, and Virulence Factor Gene Detection of Streptococcus pyogenes. Microbiol Immunol. Vol. 69. 384-388. 2025.
  • Yixuan L., Nakata M., Migita H., Matsumoto A., Oogai Y., Takebe K., Yamaguchi M., Okahashi N., Sumitomo T., Kawabata S. Identification of PilX, pilus component of Streptococcus sanguinis. J. Oral Biosci. Vol. 67: 100664. 2025.

  • Ikeda E., Yamaguchi M., Kawabata S. The Human Oral Microbial Consortium Associated With Periodontitis Attenuates Weight Loss in Dextran Sulfate Sodium-Induced Colitis. Gastro Hep Adv. Vol. 4. 100698. 2025.

  • Ikeda E., Yamaguchi M., Ono M., Kawabata S., In Vitro Acid Resistance of Pathogenic Candida Species in Simulated Gastric Fluid. Gastro Hep Adv. Vol. 4. 100591. 2025.

2024年度

  • Nakayama Y., Sasai M., Kuratani A., Okamoto M., Okuzaki D., Yamamoto K., Ono C., Yamaguchi M., Kawabata S., Shinjyo N., Okabe Y., Matsuura Y., Ato M., Yamamoto M. Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology. iScience, Vol. 28. 111975. 2025.

  • Gong W., Ono M., Yamaguchi M.†, Motooka D., Hirose Y., Higashi K., Kobayashi M., Ikeda E., Sumitomo T., Okuno R., Yamaguchi T., Kawahara R., Otsuka H., Nakanishi N., Kazawa Y., Nakagawa C., Yamaguchi R., Sakai H., Matsumoto Y., Ikebe T., Kawabata S. A comprehensive analysis of antimicrobial resistance of clinical emm89 Streptococcus pyogenes in Japan. JAC Antimicrob Resist. Vol. 7. dlaf017. 2025. †corresponding author.

  • Hata K., Wakamori K., Hirakawa-Yamamura A., Ichiyama-Kobayashi S., Yamaguchi M., Okuzaki D., Takahata Y., Murakami T., Uzawa N., Yamashiro T., Nishimura R. Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. J. Cell Physiol. Vol. 240. e31490. 2025

  • Iijima N., Yamaguchi M., Hayashi T., Rui Y., Ohira Y., Miyamoto Y., Niino M., Okuno T., Suzuki O., Oka M., Ishii J.K. miR-147-3p in pathogenic CD4+ T cells controls chemokine receptor expression for the development of experimental autoimmune diseases. J. Autoimmun. Vol. 149. 103319. 2024.
  • Takahara Y., Sumitomo T., Kono M., Takemura M., Akamastsu Y., Hirose Y., Yamaguchi M., Nakata M., Hotomi M., Kawabata S. Pneumolysin Contributes to Dysfunction of Nasal Epithelial Barrier for Promotion of Pneumococcal Dissemination into Brain Tissue. mSphere. Vol. 9. e0065524. 2024.
  • Hirose Y., Zielinski D.C., Poudel S., Rychel K., Baker J.L., Toya Y., Yamaguchi M., Heinken A., Thiele I., Kawabata S., Palsson B.O., Nizet V. A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes. mSystems. Vol. 19. e0073624. 2024.
  • Ohshima J., Abe S., Morita M., Tanaka N., Yamaguchi M., Hayashi M. Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model. Sci. Rep. Vol. 14. 15502. 2024.
  • Yamaguchi M.†, Uchihashi T., Kawabata S.† Hybrid sequence-based analysis reveals the distribution of bacterial species and genes in the oral microbiome at a high resolution. Biochem. Biophys. Rep. Vol. 38. 101717. 2024. †corresponding author.
  • Talat D., Sumitomo T., Honda-Ogawa M., Takahara Y., Mori Y., Yamaguchi M., Nakata M., Ibrahim S. M., Kawabata S. Two-component regulatory system TCS08 of a serotype 4 strain in pneumococcal pneumonia pathogenesis. J. Oral Biosci. Vol. 66. 567-574. 2024.
  • Nagata N., Kurosaka H., Higashi K., Yamaguchi M., Yamamoto S., Inubushi T., Nagata M., Ishihara Y., Yonei A., Miyashita Y., Asano Y., Sakai N., Sakata Y., Kawabata S., Yamashiro T. Characteristic craniofacial defects with novel truncated variant of USP9X. Hum Genome Var. Vol.11. 21. 2024.
  • Ikeda E., Yamaguchi M., Kawabata S., Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice. Gastro Hep Advances. Vol. 3. 461-470. 2024.

  • 山口雅也，川端重忠．基礎研究から見た化膿レンサ球菌による病態形成機構と宿主の防御機構．別冊 医学のあゆみ 臨床医のための微生物学講座 各病原体の最新知識と臨床対応，医歯薬出版．pp27-32. 2025. #再録

  • 山口雅也，川端重忠．4. 微生物．イラストでわかる歯科医学の基礎 第5版．永末書店．pp198-209. 2025.

  • 山口雅也，川端重忠．7. 口腔感染症．イラストでわかる歯科医学の基礎 第5版．永末書店．pp224-229. 2025.

2023年度

  • Kawanishi K.†, Naito-Matsui Y.†, Soares Zaramela L.†, van Sorge N.M.†, Yamaguchi M.†: Editorial: A sweet deal – Glycobiology in host-pathogen interactions. Front. Microbiol., Vol. 14. 1341820. 2023. †corresponding author. Editorial
  • Takebe K., Suzuki M., Sangawa T., Kreikemeyer B., Yamaguchi M., Uzawa N., Sumitomo T., Kawabata S., Nakata M. Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch. Microbiol., Vol. 206. 4. 2023.
  • Kubota S., Nakata M., Hirose Y., Yamaguchi M., Kreikemeyer B., Uzawa N., Sumitomo T., Kawabata S. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of mRNA level of transcriptional regulator. Microbiol. Immunol., Vol. 67. 319-333. 2023.
  • 山口雅也，川端重忠．基礎研究から見た化膿レンサ球菌による病態形成機構と宿主の防御機構．医学のあゆみ，医歯薬出版．Vol. 288. pp869-874. 2024.
  • 大野 誠之，山口 雅也．大規模比較ゲノム解析による病原細菌の進化と病態発症機構の解明．サイバーメディアHPCジャーナル．Vol. 13. pp13-16. 2023.

2022年度

  • Takemura M., Yamaguchi M.†, Kobayashi M., Sumitomo T., Hirose Y., Okuzaki D., Ono M., Motooka D., Goto K., Nakata M., Uzawa N., Kawabata S., Pneumococcal BgaA promotes host organ bleeding and coagulation in a mouse sepsis model. Front. Cell. Infect. Microbiol., Vol. 12. 844000. 2022. †corresponding author.

  • 山口雅也，川端重忠．肺炎球菌の種の壁を超える進化機構　～ 肺炎球菌は口腔レンサ球菌の遺伝子を取り込んで耐性化する～．日本歯科医師会雑誌．Vol.75. pp17-25. 2022.

2021年度

  • Wu Z.Y.*, Campeau A.*, Liu C.H., Gonzalez D.J., Yamaguchi M., Kawabata S., Lu C.H., Lai C.Y., Chiu H.C., Chang Y.C. Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome. Virulence, Vol. 12. 2633-2647. 2021.
  • Sumitomo T., Nakata M., Nagase S., Takahara Y., Honda-Ogawa M., Mori Y., Akamatsu Y., Yamaguchi M., Okamoto S., Kawabata S. GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection. mBIO, Vol. 12. e0326920. 2021.
  • Yamaguchi M., Kinjo Y., Nizet V., eds. Host-pathogen Interaction During Pneumococcal Infections. Lausanne: Frontiers Media SA. 2021. doi: 10.3389/978-2-88971-888-7, Book editor
  • Yamaguchi M.†, Kinjo Y.† Nizet V.† Editorial: Host-pathogen Interactions During Pneumococcal Infection. Front. Cell. Infect. Microbiol., Vol. 11. 752959. 2021. †corresponding author. Editorial
  • 山口雅也，川端重忠．第3章 病原微生物各論 I. グラム陽性球菌と感染症．口腔微生物学・免疫学 第5版．医歯薬出版．pp140-147. 2021.
  • 山口雅也，川端重忠．4. 微生物．イラストでわかる歯科医学の基礎 第4版．永末書店．pp209-221. 2021.
  • 山口雅也，川端重忠．7. 口腔感染症．イラストでわかる歯科医学の基礎 第4版．永末書店．pp238-244. 2021.

2020年度

  • Hirose Y., Yamaguchi M., Sumitomo T., Nakata M., Hanada T., Okuzaki D., Motooka D., Mori Y., Kawasaki H., Coady A., Uchiyama S., Hiraoka M., Zurich R.H., Amagai M., Nizet V., Kawabata S. Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep., Vol. 34. 108924. 2021.
  • Yamaguchi M.†, Myo Win H. P., Higashi K., Ono M., Hirose Y., Motooka D., Okuzaki D., Aye M. M., Htun M. M., Thu H. M., Kawabata S.† Epidemiological analysis of pneumococcal strains isolated at Yangon children's hospital in Myanmar via whole-genome sequencing-based methods. Microb. Genomics, Vol. 7. 000523. 2021. †corresponding author.
  • Hirose Y., Yamaguchi M., Takemoto N., Miyoshi-Akiyama T., Sumitomo T., Nakata M., Ikebe T., Hanada T., Yamaguchi T., Kawahara R., Okuno R., Otsuka H., Matsumoto Y., Terashima Y., Kazawa Y., Nakanishi N., Uchida K., Akiyama Y., Iwabuchi K., Nakagawa C., Yamamoto K., Nizet V., Kawabata S. Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019. Infect. Microbe Dis., Vol. 2. 160-166. 2020.
  • Yamaguchi M.†, Takemura M., Higashi K., Goto K., Hirose Y., Sumitomo T., Nakata M., Uzawa N., Kawabata S.†, Role of BgaA as a pneumococcal virulence factor elucidated by molecular evolutionary analysis. Front. Microbiol., Vol. 11. 582437. 2020. †corresponding author.
  • Otsuki M., Wada M., Yamaguchi M., Kawabata S., Maeda Y., Ikebe K. Evaluation of decontamination methods of oral biofilms formed on screw-shaped, rough and machined surface implants: an ex vivo study. Int. J. Implant Dent. Vol. 6. 18. 2020.
  • 山口雅也，川端重忠．第III編 第3章 肺炎と微生物叢．ヒト常在菌叢と生理機能・全身疾患．シーエムシー出版．pp.158-164. 2020.
  • 山口雅也．肺炎球菌による病態形成機構の解明．日本細菌学雑誌．Vol. 75. pp173-183. 2020.

2019年度

  • Sankar S., Yamaguchi M., Kawabata S., Ponnuraj K., Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine, rabbit and porcine serum albumins. Protein J., Vol. 39. 1-9. 2020.
  • Hirose Y., Yamaguchi M., Okuzaki D., Motooka D., Hamamoto H., Hanada T., Sumitomo T., Nakata M., Kawabata S. Streptococcus pyogenes transcriptome changes in inflammatory environment of necrotizing fasciitis. Appl. Environ. Microbiol., Vol. 85. e01428-19. 2019.
  • Yamaguchi M.†, Hirose Y., Takemura M., Ono M., Sumitomo T., Nakata M., Terao Y., Kawabata S.† Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. Front. Cell. Infect. Microbiol., Vol. 9. 301. 2019. †corresponding author.

  • 後藤花奈，山口雅也，川端重忠．Streptococcus pneumoniaeのコリン結合タンパク質が感染成立に果たす役割，大阪大学歯学雑誌，大阪大学歯学会．Vol. 64. pp5-7. 2019.

2018年度

  • Yamaguchi M.†, Goto K., Hirose Y., Yamaguchi Y., Sumitomo T., Nakata M., Nakano K., Kawabata S. Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae. Commun. Biol., Vol. 2. 96. 2019. †corresponding author.
  • Hirose Y., Yamaguchi M.†, Goto K., Sumitomo T., Nakata M., Kawabata S. Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis. Virulence, Vol. 9. pp1576-1587. 2018. †corresponding author.
  • Radhakrishnan D., Yamaguchi M., Kawabata S., Ponnuraj K. Streptococcus pneumoniae surface adhesin PfbA and its interaction with erythrocytes and hemoglobin. Int. J. Biol. Macromol. Vol. 120. 135-143. 2018.
  • Kurosawa M., Oda M., Domon H., Isono T., Nakamura Y., Saitoh I., Hayasaki H., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Microbiol. Immunol., Vol. 62. pp617-623. 2018.
  • Domon H., Nagai K., Maekawa T., Oda M., Yonezawa D., Takeda W., Hiyoshi T., Tamura H., Yamaguchi M., Kawabata S., Terao Y. Neutrophil elastase subverts the immune response by cleaving Toll-like receptors and cytokines in pneumococcal pneumonia. Front. Immunol., Vol. 9. 732. 2018.
  • Hirose Y., Funahashi Y., Matsukawa Y., Majima T., Yamaguchi M., Kawabata S., Gotoh M., Yamamoto T., Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals. Cytotherapy, Vol. 20. pp589-591. 2018.

  • Yamaguchi M. Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species. J. Oral Biosci. Vol. 60. pp36-40. 2018., invited review.

  • 山口雅也，川端重忠．病原レンサ球菌の感染過程における莢膜糖鎖と糖鎖分解酵素の役割．生化学．日本生化学会．Vol. 90. pp80-83. 2018.

2017年度

  • Nagai K., Domon H., Maekawa T., Oda M., Hiyoshi T., Tamura H., Yonezawa D., Arai Y., Yokoji M., Tabeta K., Habuka R., Saitoh A., Yamaguchi M., Kawabata S., Terao Y. Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol., Vol. 325. pp14-22. 2018.
  • Sumitomo T., Mori Y., Nakamura Y., Honda-Ogawa M., Nakagawa S., Yamaguchi M., Matsue H., Terao Y., Nakata M., Kawabata S. Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. Front. Cell. Infect. Microbiol., Vol. 8. 10. 2018.
  • Kurosawa M., Oda M., Domon H., Isono T., Nakamura Y., Saitoh I., Hayasaki H., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Microb. Infect., Vol. 20 pp9-18. 2018.
  • Yamaguchi M., Nakata M., Sumioka R., Hirose Y., Wada S., Akeda Y., Sumitomo T., Kawabata S. Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. Virulence, Vol. 8. pp1516-1524. 2017.
  • Beulin D.S., Radhakrishnan D., Suresh S.C., Sadasivan C., Yamaguchi M., Kawabata S., Ponnuraj K. Streptococcus pneumoniae surface protein PfbA is a versatile multi-domain and multi-ligand-binding adhesin employing different binding mechanisms. FEBS J., Vol. 284. pp3404–3421. 2017.
  • Oda M., Domon H., Kurosawa M., Isono T., Maekawa T., Yamaguchi M., Kawabata S., Terao Y. Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. Front. Cell. Infect. Microbiol. Vol. 7. 300. 2017.

  • Yamaguchi M., Kawabata S. Streptococcal Enolase and Immune Evasion, In Moonlighting proteins: Novel virulence factors in bacterial infections. Ed: Henderson B. Wiley Blackwell. pp269-289. 2017. invited book chapter.

  • 山口雅也．病原レンサ球菌における莢膜と糖鎖分解酵素．大阪大学歯学雑誌，大阪大学歯学会．Vol. 61. pp1-4. 2017.

2016年度

  • Honda-Ogawa M., Sumitomo T., Mori Y., Hamd D.T., Ogawa T., Yamaguchi M., Nakata M., Kawabata S. Streptococcus pyogenes endopeptidase O contributes to evasion from complement-mediated bacteriolysis via binding to human complement factor C1q. J. Biol. Chem. Vol. 292. pp4244-4254. 2017.
  • Sumioka R., Nakata M., Okahashi N., Li Y., Wada S., Yamaguchi M., Sumitomo T., Hayashi M., Kawabata S. Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. PLoS One, Vol. 12. e0172223. 2017.
  • Oogai Y., Yamaguchi M., Kawada-Matsuo M., Sumitomo T., Kawabata S., Komatsuzawa H. Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum. Appl. Environ. Microbiol. Vol. 82. pp6150-6157. 2016.
  • Yamaguchi M.†, Hirose Y., Nakata M., Uchiyama S., Yamaguchi Y., Goto K., Sumitomo T., Lewis A.L., Kawabata S., Nizet V. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci. Rep. Vol. 6. 28852. 2016. †corresponding author.
  • Hirose Y., Yamaguchi M., Kawabata S., Murakami M., Nakashima M., Gotoh M., Yamamoto T. Effects of Extracellular pH on Dental Pulp Cells in vitro. J. Endodont. Vol. 42. pp.735-741. 2016.
  • Sumitomo T., Nakata M., Higashino M., Yamaguchi M., Kawabata S. Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Sci. Rep., Vol. 6. 20069. 2016.

2015年度

  • Hirose Y., Yamamoto T., Nakashima M., Funahashi Y., Matsukawa Y., Yamaguchi M., Kawabata S., Gotoh M. Injection of dental pulp stem cells promotes healing of damaged bladder tissue in a rat model of chemically induced cystitis. Cell Transplant. Vol. 25. pp425-436. 2016.
  • 山口雅也．肺炎球菌と赤血球の相互作用の解明，一般財団法人 岩垂育英会 創立50周年記念誌，一般財団法人 岩垂育英会．pp18-19．2015.

2014年度

  • Kang S., Watanabe M., Jacobs J.C., Yamaguchi M., Dahesh S., Nizet V., Leyh T.S., Silverman R.B. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. Eur. J. Med. Chem. Vol. 90C. pp448-461. 2015.
  • Henningham A.*, Yamaguchi M.*, Aziz R.K., Kuipers K., Buffalo C.Z., Dahesh S., Choudhury B., Van Vleet J., Yamaguchi Y., Seymour L.M., Ben Zakour N.L., He L., Smith H.V., Grimwood K., Beatson S.A., Ghosh P., Walker M.J., Nizet V., Cole J.N. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J. Biol. Chem. Vol. 289. pp32303-32315. 2014. *equally contributed.
  • Beulin D.S., Yamaguchi M., Kawabata S., Ponnuraj K. Crystal structure of PfbA, a surface adhesion of Streptococcus pneumoniae, provides hints into its interaction with fibronectin. Int. J. Biol. Macromol., Vol. 64. pp168-173. 2014.

2013年度

  • Yamaguchi M., Terao Y., Mori-Yamaguchi Y., Domon H., Sakaue Y., Yagi T., Nishino K., Yamaguchi A., Nizet V., Kawabata S. Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One, Vol. 8. e77282. 2013.

  • Yamaguchi M., Terao Y., Kawabata S. Pleiotropic virulence factor - Streptococcus pyogenes fibronectin-binding proteins. Cell. Microbiol., Vol. 15. pp503-511. 2013. Review

2012年度

  • Sano R., Hou Y.C., Hedvat M., Correa R.G., Shu C.W., Krajewska M., Diaz P.W., Quarato G., Gottlieb R.A., Yamaguchi M., Nizet V., Dahl R., Thomas D.D., Tait S.W., Green D.R., Fisher P.B., Matsuzawa S., Reed J.C. Endoplasmic Reticulum Protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy. Genes Dev., Vol. 26. pp1041-1054. 2012.

2011年度

  • Mori Y.*, Yamaguchi M.*, Terao Y., Hamada S., Ooshima T., Kawabata S. α-enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps. J. Biol. Chem., Vol. 287. pp10472–10481. 2012. *equally contributed.

  • Sumitomo T., Nakata M., Yamaguchi M., Terao Y., Kawabata S. S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. J. Med. Microbiol., Vol. 61. pp101-108. 2012.

2010年度

  • Okahashi N., Nakata M., Terao Y., Isoda R., Sakurai A., Sumitomo T., Yamaguchi M., Kimura R.K., Oiki E., Kawabata S., Ooshima T. Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. Microb. Pathog., Vol. 50. 148-154. 2011.
  • Okahashi, N., Nakata M., Sakurai A., Terao Y., Hoshino T., Yamaguchi M., Isoda R., Sumitomo T., Nakano K., Kawabata S., Ooshima T. Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem. Biophys. Res. Commun., Vol. 391. pp1192-1196. 2010.
  • 山口雅也，寺尾 豊，川端重忠．歯科用インプラントと感染症，歯界展望，医歯薬出版．Vol. 116. pp1154-1155. 2010.
  • 山口雅也，寺尾 豊，川端重忠．肺炎レンサ球菌 最新の知見, 大阪大学歯学雑誌，大阪大学歯学会．Vol. 54. pp49-52. 2010.

2009年度

  • Yamaguchi M., Minamide Y., Terao Y., Isoda R., Ogawa T., Yokota S., Hamada S., Kawabata S. Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochem. Biophys. Res. Commun., Vol. 390. pp155-160. 2009.

  • 山口雅也，寺尾 豊，川端重忠．肺炎レンサ球菌の新規ワクチン抗原の検索．大阪大学歯学雑誌，大阪大学歯学会．Vol. 53. pp61-65. 2009.

2008年度

  • Yamaguchi M., Terao Y., Mori Y., Hamada S., Kawabata S. PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis. J. Biol. Chem., Vol. 283. pp36272-36279. 2008.

2007年度

  • Terao Y., Mori Y., Yamaguchi M., Shimizu Y., Ooe K., Hamada S., Kawabata S. Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. J. Biol. Chem., Vol. 283. pp6253-6260. 2008.
  • 川端重忠，山口雅也．A群レンサ球菌感染症のメカニズム．医学のあゆみ，医歯薬出版．Vol. 223． pp601-605. 2007.

2006年度

  • Yamaguchi M., Terao Y., Ogawa T., Takahashi T. Hamada S., Kawabata S. Role of Streptococcus sanguinis sortaseA in bacterial colonization. Microb. Infect., Vol. 8. pp2791-2796. 2006.
  • Terao Y., Yamaguchi M., Hamada S., Kawabata S. Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. J. Biol. Chem., Vol. 281. pp14215-14223. 2006.

トップページ「新着情報」欄に表示する画像

研究成果 ／ イベント ／ 公募 ／ お知らせ のいずれかを入力してください。

お知らせ