Laboratory Animal Resource Bank(LARB)

1. Members

2. Background and objectives

A variety of animal models for human diseases play essential roles in the biomedical research including pathogenetic analysis and the development of new drugs for rare and/or incurable diseases. To facilitate the research and development, we are developing new animal models of diseases by establishing spontaneous mutant mice, transplanting human organs or tissues to super SCID mice, and generating gene-modified animals. We are also maintaining, preserving, and providing these model animals and developing related technologies such as reproductive biotechnologies.

3. Overview of our research

I. Development of animal models for human diseases and related technologies

We are developing and establishing new animal models for human diseases focusing on rare and/or incurable diseases including inherited metabolic disorders (e.g., lysosomal storage diseases), intractable nephrosis, cardiomyopathy, and osteoarthrosis. In addition, we are developing and improving the reproductive techniques such as in vitro fertilization and embryo/gamete/ovary cryopreservation in order to maintain/preserve and provide safely/effectively the valuable model animals.

Laboratory of Animal Models for Human Diseases