研究実績 2005以前

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• 2005以前

2005年以前

原著論文

鎌田　春彦

Tsutsumi Y, Kihira T, Tsunoda S, Kamada H, Nakagawa S, Kaneda Y, Kanamori T, Mayumi T. Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation. J Pharmacol Exp Ther., 278:1006-1011. 1996.[PubMed]

Tsutsumi Y, Tsunoda S, Kamada H, Kihira T, Nakagawa S, Kaneda Y, Kanamori T, Mayumi T. Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency. Br J Cancer., 74:1090-1095. 1996.[PubMed]

Tsutsumi Y, Tsunoda S, Kaneda Y, Kamada H, Kihira T, Nakagawa S, Yamamoto Y, Horisawa Y, Mayumi T. In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors. Jpn J Cancer Res. 87:1078-1085, 1996.[PubMed]

Tsutsumi Y, Tsunoda S, Kamada H, Kihira T, Kaneda Y, Ohsugi Y, Mayumi T. PEGylation of interleukin-6 effectively increases its thrombopoietic potency. Thromb Haemost., 77:168-173. 1997.[PubMed]

Kaneda Y, Yamamoto Y, Tsunoda S, Kamada H, Tsutsumi Y, Hirano T, Mayumi T. Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency. Biochem Biophys Res Commun., 239:160-165. 1997.[PubMed]

Maeda M, Kawasaki K, Mu Y, Kamada H, Tsutsumi Y, Smith TJ, Mayumi T. Amino acids and peptides. XXXIII. A bifunctional poly(ethylene glycol) hybrid of laminin-related peptides. Biochem Biophys Res Commun., 248:485-489. 1998.[PubMed]

Kaneda Y, Yamamoto Y, Kamada H, Tsunoda S, Tsutsumi Y, Hirano T, Mayumi T. Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice. Cancer Res., 58:290-295. 1998.[PubMed]

Tsunoda S, Ishikawa T, Yamamoto Y, Kamada H, Koizumi K, Matsui J, Tsutsumi Y, Hirano T, Mayumi T. Enhanced antitumor potency of polyethylene glycolylated tumor necrosis factor-alpha: a novel polymer-conjugation technique with a reversible amino-protective reagent. J Pharmacol Exp Ther., 290:368-372. 1999.[PubMed]

Nishiyama Y, Yoshikawa T, Kurita K, Hojo K, Kamada H, Tsutsumi Y, Mayumi T, Kawasaki K. Regioselective conjugation of chitosan with a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg, and evaluation of its inhibitory effect on experimental cancer metastasis. Chem Pharm Bull (Tokyo)., 47:451-453. 1999.[PubMed]

Mu Y, Kamada H, Kaneda Y, Yamamoto Y, Kodaira H, Tsunoda S, Tsutsumi Y, Maeda M, Kawasaki K, Nomizu M, Yamada Y, Mayumi T. Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells. Biochem Biophys Res Commun., 255:75-79. 1999.[PubMed]

Mu Y, Kamada H, Kodaira H, Sato K, Tsutsumi Y, Maeda M, Kawasaki K, Nomizu M, Yamada Y, Mayumi T. Bioconjugation of laminin-related peptide YIGSR with polyvinyl pyrrolidone increases its antimetastatic effect due to a longer plasma half-life. Biochem Biophys Res Commun., 264:763-767. 1999.[PubMed]

Kamada H, Tsutsumi Y, Tsunoda S, Kihira T, Kaneda Y, Yamamoto Y, Nakagawa S, Horisawa Y, Mayumi T. Molecular design of conjugated tumor necrosis factor-alpha: synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha. Biochem Biophys Res Commun., 257:448-453. 1999.[PubMed]

Tsunoda S, Kamada H, Yamamoto Y, Ishikawa T, Matsui J, Koizumi K, Kaneda Y, Tsutsumi Y, Ohsugi Y, Hirano T, Mayumi T. Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice. J Control Release., 68:335-341. 2000.[PubMed]

Kamada H, Tsutsumi Y, Kihira T, Tsunoda S, Yamamoto Y, Mayumi T. In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha. Biochem Biophys Res Commun., 268:809-813. 2000.[PubMed]

Kamada H, Tsutsumi Y, Yamamoto Y, Kihira T, Kaneda Y, Mu Y, Kodaira H, Tsunoda SI, Nakagawa S, Mayumi T. Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice. Cancer Res., 60:6416-6420. 2000.[PubMed]

Hojo K, Maeda M, Mu Y, Kamada H, Tsutsumi Y, Nishiyama Y, Yoshikawa T, Kurita K, Block LH, Mayumi T, Kawasaki K. Facile synthesis of a chitosan hybrid of a laminin-related peptide and its antimetastatic effect in mice. J Pharm Pharmacol., 52:67-73. 2000.[PubMed]

Tsunoda S, Ishikawa T, Watanabe M, Kamada H, Yamamoto Y, Tsutsumi Y, Hirano T, Mayumi T. Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent. Br J Haematol., 112:181-188. 2001.[PubMed]

Koizumi K, Tsutsumi Y, Kamada H, Yoshioka Y, Watanabe M, Yamamoto Y, Okamoto T, Mukai Y, Nakagawa S, Tani Y, Mayumi T. Incorporation of adult organ-derived endothelial cells into tumor blood vessel. Biochem Biophys Res Commun., 306:219-24. 2003.[PubMed]

Kamada H, Tsutsumi Y, Sato-Kamada K, Yamamoto Y, Yoshioka Y, Okamoto T, Nakagawa S, Nagata S, Mayumi T. Synthesis of a poly(vinylpyrrolidone -co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting. Nat Biotechnol., 21:399-404. 2003.[PubMed]

Yuda H, Adachi Y, Taguchi O, Gabazza EC, Hataji O, Fujimoto H, Tamaki S, Nishikubo K, Fukudome K, D'Alessandro-Gabazza CN, Maruyama J, Izumizaki M, Iwase M, Homma I, Inoue R, Kamada H, Hayashi T, Kasper M, Lambrecht BN, Barnes PJ, Suzuki K. Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Blood., 103: 2196-2204. 2004.[PubMed]

Yoshioka Y, Tsutsumi Y, Kamada H, Kihira T, Tsunoda S, Yamamoto Y, Okamoto T, Shibata H, Mukai Y, Taniai M, Shimizu T, Kawamura M, Abe Y, Nakagawa S, Mayumi T. Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy. Biol Pharm Bull., 27:437-439. 2004.[PubMed]

Yoshioka Y, Tsutsumi Y, Mukai Y, Shibata H, Okamoto T, Kaneda Y, Tsunoda S, Kamada H, Koizumi K, Yamamoto Y, Mu Y, Kodaira H, Sato-Kamada K, Nakagawa S, Mayumi T. Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen. J Biomed Mater Res A., 70:219-223. 2004.[PubMed]

Yamamoto Y, Tsutsumi Y, Yoshioka Y, Kamada H, Sato-Kamada K, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier. J Control Release., 95:229-237. 2004.[PubMed]

Wakita T, Hayashi T, Nishioka J, Tamaru H, Akita N, Asanuma K, Kamda H, Gabazza EC, Ido M, Kawamura J, Suzuki K. Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. Int J Cancer., 108:516-523. 2004.[PubMed]

Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y. Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin Cancer Res., 10:8293-8300. 2004.[PubMed]

Okamoto T, Mukai Y, Yoshioka Y, Shibata H, Kawamura M, Yamamoto Y, Nakagawa S, Kamada H, Hayakawa T, Mayumi T, Tsutsumi Y. Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen. Biochem Biophys Res Commun., 323:583-591. 2004.[PubMed]

Kodaira H, Tsutsumi Y, Yoshioka Y, Kamada H, Kaneda Y, Yamamoto Y, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. The targeting of anionized polyvinylpyrrolidone to the renal system. Biomaterials., 25:4309-4315. 2004.[PubMed]

Kaneda Y, Tsutsumi Y, Yoshioka Y, Kamada H, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. The use of PVP as a polymeric carrier to improve the plasma half-life of drugs. Biomaterials., 25:3259-3266. 2004.[PubMed]

Kamada H, Tsutsumi Y, Yoshioka Y, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy. Clin Cancer Res., 10:2545-2550. 2004.[PubMed]

Kamada H, Hattori K, Hayashi T, Suzuki K. In vitro evaluation of blood coagulation activation and microthrombus formation by a microchannel array flow analyzer. Thromb Res., 114:195-203. 2004.[PubMed]

Hayashi T, Nishioka J, Kamada H, Asanuma K, Kondo H, Gabazza EC, Ido M, Suzuki K. Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions. J Thromb Haemost., 2:949-961. 2004.[PubMed]

Gabazza EC, Taguchi O, Kamada H, Hayashi T, Adachi Y, Suzuki K. Progress in the understanding of protease-activated receptors. Int J Hematol., 79:117-122. 2004.[PubMed]

Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y (2004) Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin Cancer Res 10, 8293-8300.[PubMed]

Kamada H, Tsutsumi Y, Sato-Kamada K, Yamamoto Y, Yoshioka Y, Okamoto T, Nakagawa S, Nagata S, Mayumi T (2003) Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting. Nat Biotechnol 21, 399-404.[PubMed]