研究実績 2022

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2022年度

原著論文

鎌田　春彦

Yamaji R, Nakagawa O, Kishimoto Y, Fujii A, Matsumura T, Nakayama T, Kamada H, Osawa T, Yamaguchi T, Obika S. Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides. Bioorg Med Chem. 2022 72:116972. doi: 10.1016/j.bmc. 2022.116972.

Higashisaka K, Takeya S, Kamada H, Obana M, Maeda M, Kabayama M, Yamamoto K, Ishida N, Isaka R, Tsujino H, Nagano K, Tomiyama N, Rakugi H, Fujio Y, Kamide K, Tsutsumi Y. Identification of biomarkers of chronic kidney disease among kidney-derived proteins. Clin Proteomics. 2022 19(1):3. doi: 10.1186/s12014-021-09340-y.

Akiba H, Fujita J, Ise T, Nishiyama K, Miyata T, Kato T, Namba K, Ohno H, Kamada H, Nagata S, Tsumoto K, Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection., bioRxiv 2022.12.15.520217; doi: https://doi.org/10.1101/2022.12.15.520217

Tanaka Y, Tanioku Y, Nakayama T, Aso K, Yamaguchi T, Kamada H, Obika S. Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities.　 Bioorg Med Chem. 2023 Mar 1;81:117192. doi: 10.1016/j.bmc.2023. 117192.

Suzuki K, Tajima M, Tokumaru Y, Oshiro Y, Nagata S, Kamada H, Kihara M, Nakano K, Honjo T, Ohta A. Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases. Sci Immunol. 2023 8(79):eadd4947. doi: 10.1126/sciimmunol.add4947.