研究実績 2023

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2023年度

原著論文

鎌田　春彦

Nishiyama K, Akiba H, Nagata S, Tsumoto K, Kamada H, Ohno H. A Proximity-Induced Fluorogenic Reaction Triggered by Antibody-Antigen Interactions with Adjacent Epitopes. Angew Chem Int Ed Engl. 2023 Jul 24;62(30):e202306431. doi: 10.1002/anie.202306431.

Inoue M, Tsuji Y, Ueno R, Miyamoto D, Tanaka K, Moriyasu Y, Shibata S, Okuda M, Ando D, Abe Y, Kamada H, Tsunoda SI. Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells. Sci Rep. 2023 Aug 23;13(1):13762. doi: 10.1038/s41598-023-40925-9.

Akiba H, Fujita J, Ise T, Nishiyama K, Miyata T, Kato T, Namba K, Ohno H, Kamada H, Nagata S, Tsumoto K. Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol. 2023 Sep 27;6(1):987. doi: 10.1038/s42003-023-05326-8.

Inoue M, Tsuji Y, Kashiwada A, Yokoyama A, Iwata A, Abe Y, Kamada H, Tsunoda SI. An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering, Biochem Biophys Res Commun. 2024 Feb 19:697:149498. doi: 10.1016/j.bbrc.2024.149498.